{"id":70,"date":"2020-07-16T21:26:17","date_gmt":"2020-07-16T21:26:17","guid":{"rendered":"https:\/\/lcaselab.org\/?page_id=70"},"modified":"2026-10-21T17:56:50","modified_gmt":"2026-10-21T17:56:50","slug":"publications","status":"publish","type":"page","link":"https:\/\/lcaselab.org\/?page_id=70","title":{"rendered":"Publications"},"content":{"rendered":"\n
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Preprints<\/strong><\/h4>\n\n\n\n

Ullo MF, Tillman DE, Coban H, Stratton KG, Baynes DD, Alexander-Katz A, Case LB<\/strong>. “An intrinsically disordered adaptor protein controls the size and composition of EGFR condensates on membranes.” bioRxiv 2026. https:\/\/doi.org\/10.64898\/2026.10.15.759085<\/a><\/p>\n\n\n\n

Ghosal A, *Lea NE, #Case LB<\/strong>, and #GrandPre T. \u201cPrinciples of client enrichment in multicomponent biomolecular condensates.\u201d arXiv 2026. https:\/\/arxiv.org\/abs\/2601.11450<\/a> <\/p>\n\n\n\n

+<\/sup>Savinov A, Sadasivan J, White K, Rubien JD, Li GW, +<\/sup>Case LB<\/strong>. \u201cAI-discovered protein fragments as generalizable regulators of biomolecular condensates.\u201d bioRxiv 2026. https:\/\/doi.org\/10.64898\/2026.05.08.723928<\/a> .<\/p>\n\n\n\n

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Publications<\/strong><\/h4>\n\n\n\n

Aierken D et al., including Case LB.<\/strong> \u201cRoadmap for condensates in cell biology<\/a>.\u201d PRX Life<\/em>. 2026 4: 032501 PDF<\/a> [original version: arXiv Preprint<\/a>]<\/p>\n\n\n\n

Lea NE and Case LB<\/strong>. “Kinase condensates enrich ATP and trigger autophosphorylation<\/a>“ Cell Reports<\/em>. 2026. PDF<\/a> [original version: BioRxiv Preprint<\/a>].<\/p>\n\n\n\n

Cheng X and Case LB<\/strong>. “Condensates control the actin cytoskeleton<\/a>” Development Cell<\/em>. 2025 60: 1519-1520. PDF<\/a><\/p>\n\n\n\n

Litschel T, Kelley CF, Cheng X, Babl L, Mizuno N, Case LB<\/strong>, Schwille P. “Membrane-induced 2D phase separation of the focal adhesion protein talin<\/a>” Nature Communications. <\/em>2024. 15: 4986. PDF<\/a> [original version: BioRxiv Preprint<\/a>]<\/p>\n\n\n\n

Cheng X and Case LB<\/strong> \u201cPhase separation in chemical and mechanical signal transduction<\/a>” Current Opinion in Cell Biology.<\/em> 2023. 85: 102243. PDF<\/a><\/p>\n\n\n\n

Ullo MF and Case LB<\/strong> \u201cHow cells sense and integrate information from different sources<\/a>” WIRES Mechanisms of Disease.<\/em> 2023. e1604. PDF<\/a> <\/p>\n\n\n\n

Cheng X, Ullo MF, Case LB<\/strong> \u201cReconstitution of phase-separated signaling clusters and actin polymerization on supported lipid bilayers<\/a>” Frontiers in Cell and Developmental Biology.<\/em> 2022. 10. PDF<\/a> <\/p>\n\n\n\n

Case LB<\/strong> \u201cMembranes regulate biomolecular condensates<\/a>” Nature Cell Biology.<\/em> 2022. 24 (4), 404-405. PDF<\/a> <\/p>\n\n\n\n

Case LB<\/strong>, De Pasquale M, Henry L, Rosen MK \u201cSynergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation<\/a>” eLife.<\/em> 2022. 11<\/strong>, e72588 PDF<\/a> [original version: BioRxiv Preprint<\/a>].<\/p>\n\n\n\n

Case LB<\/strong>, Zhang X, Ditlev JA, Rosen MK \u201cStoichiometry controls activity of phase separated clusters of actin signaling proteins<\/a>\u201d  Science.<\/em> 2019. 363 (4631): 1093-1097. [News Highlights by Science, Nature Reviews Molecular Cell Biology<\/em>, and Faculty1000<\/em>] PDF<\/a><\/p>\n\n\n\n

+<\/sup>Case LB<\/strong>, +<\/sup>Ditlev JA, +<\/sup>Rosen MK \u201cRegulation of transmembrane signaling by phase separation.<\/a>\u201d  Annual Review of Biophysics.<\/em> 2019. 48:465-49. PDF<\/a><\/p>\n\n\n\n

+<\/sup>Ditlev JA, +<\/sup>Case LB<\/strong>, +<\/sup>Rosen MK \u201cWho\u2019s In and Who\u2019s Out – Compositional Control of Biomolecular Condensates<\/a>.\u201d  Journal of Molecular Biology. <\/em>2018. 430 (23): 4666-4684. PDF<\/a><\/p>\n\n\n\n

Thompson PM, Ramachandran, Case<\/strong> LB<\/strong>, Toblert CE, Tandon A, Pershad M, Dokholyan NV, Waterman CM, Campbell SL, \u201cA Structural Model for Vinculin Insertion into PIP2-Containing Membranes and the Effect of Insertion on Vinculin Activation and Localization<\/a>\u201d  Structure<\/em>.  2017. 25 (2): 264-275.  PDF<\/a><\/p>\n\n\n\n

Case LB <\/strong>and Waterman CM, \u201cIntegration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch<\/a>.\u201d  Nature Cell Biology, <\/em>2015. 17 (8): 955-963. PDF<\/a><\/p>\n\n\n\n

Case LB<\/strong>, Baird MA, Shtengel G, Campbell SL, Davidson MW, Hess HF and Waterman CM.  \u201cMolecular mechanisms of vinculin activation and nanoscale spatial organization at focal adhesions<\/a>\u201d.  Nature Cell Biology<\/em>, 2015. 17(7):880-892. [News Highlights by Nature Cell Biology <\/em>and Faculty1000<\/em>] PDF<\/a><\/p>\n\n\n\n

Pasapera AM, Plotnikov SV, Fischer RS, Case LB<\/strong>, Egelhoff TT  and Waterman CM.  \u201cRac1-dependent phosphorylation and focal adhesion recruitment of myosin IIA regulates migration and mechanosensing<\/a>\u201d.  Current Biology, 2015. <\/em>25(2):175-86. PDF<\/a><\/p>\n\n\n\n

Case LB<\/strong> and Waterman CM  \u201cAdhesive F-actin waves: A novel integrin-mediated adhesion complex coupled to ventral actin polymerization.<\/a>\u201d  PLoS One.<\/em> 2011. 6(11): e26631. PDF<\/a><\/p>\n\n\n\n

Quintero OA, Divito MM, Adikes RC, Kortan MB, Case LB<\/strong>, Lier AJ, Panaretos NS, Slater SQ, Rengarajan M, Feliu M, Cheney RE \u201cHuman Myo19 Is a Novel Myosin that Associates with Mitochondria<\/a>.\u201d  Current Biology<\/em>.  2009. 19(23): 2008-2013. PDF<\/a><\/p>\n\n\n\n

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+ Co-Corresponding Authors<\/p>\n\n\n\n

Up-to-date publication list at NCBI<\/a>.<\/p>\n\n\n\n

Open Access versions of our publications available through DSpace@MIT<\/a>.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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