Preprints

Litschel T, Kelley CF, Cheng X, Babl L, Mizuno N, Case LB, Schwille P. “Membrane-induced 2D phase separation of focal adhesion proteins” bioRxiv Preprint. Uploaded 1 April 2023

Publications

Cheng X and Case LBPhase separation in chemical and mechanical signal transductionCurrent Opinion in Cell Biology. 2023. 85: 102243. PDF

Ullo MF and Case LBHow cells sense and integrate information from different sourcesWIRES Mechanisms of Disease. 2023. e1604. PDF

Cheng X, Ullo MF, Case LBReconstitution of phase-separated signaling clusters and actin polymerization on supported lipid bilayersFrontiers in Cell and Developmental Biology. 2022. 10. PDF

Case LBMembranes regulate biomolecular condensatesNature Cell Biology. 2022. 24 (4), 404-405. PDF

Case LB, De Pasquale M, Henry L, Rosen MK “Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formationeLife. 2022. 11, e72588 PDF [original version: BioRxiv Preprint].

Case LB, Zhang X, Ditlev JA, Rosen MK “Stoichiometry controls activity of phase separated clusters of actin signaling proteins”  Science. 2019. 363 (4631): 1093-1097. [News Highlights by Science, Nature Reviews Molecular Cell Biology, and Faculty1000] PDF

+Case LB+Ditlev JA, +Rosen MK “Regulation of transmembrane signaling by phase separation.”  Annual Review of Biophysics. 2019. 48:465-49. PDF

+Ditlev JA, +Case LB+Rosen MK “Who’s In and Who’s Out – Compositional Control of Biomolecular Condensates.”  Journal of Molecular Biology. 2018. 430 (23): 4666-4684. PDF

Thompson PM, Ramachandran, Case LB, Toblert CE, Tandon A, Pershad M, Dokholyan NV, Waterman CM, Campbell SL, “A Structural Model for Vinculin Insertion into PIP2-Containing Membranes and the Effect of Insertion on Vinculin Activation and Localization”  Structure.  2017. 25 (2): 264-275.  PDF

Case LB and Waterman CM, “Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch.”  Nature Cell Biology, 2015. 17 (8): 955-963. PDF

Case LB, Baird MA, Shtengel G, Campbell SL, Davidson MW, Hess HF and Waterman CM.  “Molecular mechanisms of vinculin activation and nanoscale spatial organization at focal adhesions”.  Nature Cell Biology, 2015. 17(7):880-892. [News Highlights by Nature Cell Biology and Faculty1000] PDF

Pasapera AM, Plotnikov SV, Fischer RS, Case LB, Egelhoff TT  and Waterman CM.  “Rac1-dependent phosphorylation and focal adhesion recruitment of myosin IIA regulates migration and mechanosensing”.  Current Biology, 2015. 25(2):175-86. PDF

Case LB and Waterman CM  “Adhesive F-actin waves: A novel integrin-mediated adhesion complex coupled to ventral actin polymerization.”  PLoS One. 2011. 6(11): e26631. PDF

Quintero OA, Divito MM, Adikes RC, Kortan MB, Case LB, Lier AJ, Panaretos NS, Slater SQ, Rengarajan M, Feliu M, Cheney RE “Human Myo19 Is a Novel Myosin that Associates with Mitochondria.”  Current Biology.  2009. 19(23): 2008-2013. PDF

+ Co-Corresponding Authors

Up-to-date publication list at NCBI.

Open Access versions of our publications available through DSpace@MIT.